Prof. Bongani Mawethu Mayosi, a prominent South African cardiologist and member of the Lancet NCDI Poverty Commission, died on July 27, 2018, at the age of 51. Dr. Mayosi dedicated his life’s work to clinical care, research, and advocacy to address neglected cardiac diseases that disproportionately affect poor and vulnerable populations in Africa. His reputation for kindness, collegiality and humility will long be remembered and his colleagues in South Africa and across the world will continue to honor his mission and work in his memory.